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Linda H Malkas Selected Research

Proliferating Cell Nuclear Antigen (PCNA)

6/2020Molecular Targeting of Cancer-Associated PCNA Interactions in Pancreatic Ductal Adenocarcinoma Using a Cell-Penetrating Peptide.
12/2018The Anticancer Activity of a First-in-class Small-molecule Targeting PCNA.
1/2016Validating the disruption of proliferating cell nuclear antigen interactions in the development of targeted cancer therapeutics.
12/2015The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells.
3/2015Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response.
2/2015A Peptide mimicking a region in proliferating cell nuclear antigen specific to key protein interactions is cytotoxic to breast cancer.
11/2014Expression of a novel peptide derived from PCNA damages DNA and reverses cisplatin resistance.
1/2014A PCNA-derived cell permeable peptide selectively inhibits neuroblastoma cell growth.
6/2012Small-molecule targeting of proliferating cell nuclear antigen chromatin association inhibits tumor cell growth.
5/2011Elevated expression of cancer-associated proliferating cell nuclear antigen in high-grade prostatic intraepithelial neoplasia and prostate cancer.
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Linda H Malkas Research Topics

Disease

31Neoplasms (Cancer)
10/2021 - 02/2005
13Neuroblastoma
12/2015 - 02/2005
10Breast Neoplasms (Breast Cancer)
03/2015 - 08/2002
4Adenocarcinoma
06/2020 - 01/2007
2Carcinogenesis
02/2008 - 11/2002
1Necrosis
10/2021
1Pancreatic Neoplasms (Pancreatic Cancer)
06/2020
1Triple Negative Breast Neoplasms
02/2015
1Glioblastoma (Glioblastoma Multiforme)
01/2014
1Genomic Instability
01/2014
1Ovarian Neoplasms (Ovarian Cancer)
10/2013
1Prostatic Neoplasms (Prostate Cancer)
05/2011
1Prostatic Intraepithelial Neoplasia
05/2011
1Barrett Esophagus (Barrett's Esophagus)
01/2007
1Ataxia Telangiectasia (Louis Bar Syndrome)
10/2005
1Lung Neoplasms (Lung Cancer)
02/2005
1Infections
08/2002
1Myotoxicity
08/2002

Drug/Important Bio-Agent (IBA)

13Proliferating Cell Nuclear Antigen (PCNA)IBA
06/2020 - 09/2006
8Peptides (Polypeptides)IBA
10/2021 - 01/2006
8Proteins (Proteins, Gene)FDA Link
06/2020 - 11/2002
8Protein Isoforms (Isoforms)IBA
12/2018 - 09/2006
8Biomarkers (Surrogate Marker)IBA
06/2015 - 02/2005
4DNA (Deoxyribonucleic Acid)IBA
12/2018 - 01/2006
3DNA synthesomeIBA
01/2016 - 07/2005
3Phosphotransferases (Kinase)IBA
01/2013 - 10/2005
3Blood Proteins (Serum Proteins)IBA
10/2007 - 04/2006
2Pharmaceutical PreparationsIBA
10/2021 - 06/2015
2Amino AcidsFDA Link
06/2020 - 11/2014
2Cisplatin (Platino)FDA LinkGeneric
12/2018 - 11/2014
2Small Interfering RNA (siRNA)IBA
03/2015 - 06/2012
2polyacrylamideIBA
09/2009 - 02/2005
2Biological ProductsIBA
08/2009 - 08/2002
1Radioisotopes (Radionuclides)IBA
10/2021
1Cell-Penetrating PeptidesIBA
06/2020
1Dosage Forms (Dosage Form)IBA
12/2018
1RNA (Ribonucleic Acid)IBA
06/2015
1AntimetabolitesIBA
06/2015
1Ribonucleotide Reductases (Ribonucleotide Reductase)IBA
06/2015
1Glutamic Acid (Glutamate)FDA Link
03/2015
1EnzymesIBA
03/2015
1MethyltransferasesIBA
03/2015
1Arginine (L-Arginine)FDA Link
02/2015
1berbamine (penduline)IBA
01/2014
1DNA-Directed DNA Polymerase (Polymerases, DNA)IBA
10/2013
1NucleotidesIBA
10/2013
1pyrimidineIBA
10/2013
1purineIBA
10/2013
1TOR Serine-Threonine KinasesIBA
01/2013
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
01/2013
1tyrosine receptor (receptor, tyrosine)IBA
01/2013
1ChromatinIBA
06/2012
1Nuclear Proteins (Protein, Nuclear)IBA
03/2011
1Doxorubicin (Adriamycin)FDA LinkGeneric
09/2009
1RNA primersIBA
04/2009
1Polysaccharides (Glycans)IBA
07/2008
1SugarsIBA
07/2008
1Reactive Oxygen Species (Oxygen Radicals)IBA
02/2008
1AntioxidantsIBA
02/2008
1Oxidants (Oxidizing Agents)IBA
02/2008
1AlbuminsIBA
10/2007
1Immunoglobulin kappa-Chains (kappa-Chain, Immunoglobulin)IBA
10/2007
1Acute-Phase Proteins (Acute-Phase Protein)IBA
10/2007
1DNA Polymerase IIIIBA
12/2006
1Mitogen-Activated Protein KinasesIBA
07/2006
1L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA
04/2006
1Phosphopyruvate Hydratase (Enolase)IBA
04/2006
1U 0126 (UO 126)IBA
01/2006
1Serum-Free Culture MediaIBA
01/2006
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2006
1Ataxia Telangiectasia Mutated ProteinsIBA
10/2005
1A-Form DNA (A-DNA)IBA
07/2005
1Glucose (Dextrose)FDA LinkGeneric
02/2005
1DNA Polymerase iotaIBA
08/2004
1PoisonsIBA
08/2002

Therapy/Procedure

9Therapeutics
10/2021 - 01/2006
2Drug Therapy (Chemotherapy)
10/2021 - 11/2014
2Lasers (Laser)
09/2009 - 08/2007